The Drosophila mimica subgroup is revised, including descriptions of 10 new species (D. acanthos Kam & Perreira, D. antecedens Kam & Perreira, D. chimera Kam & Perreira, D. echinostoma Kam & Perreira, D. gagné Kam & Perreira, D. inebria Kam & Perreira, D. lobatopalpus Kam & Perreira, D. ma’ema’e Kam & Perreira, D. odontostoma Kam & Perreira, D. xenophaga Kam & Perrierra) and a needed lectotype designation for Drosophila kauluai Bryan. We erect seven species complexes; conjectura, flavibasis, infuscata, involuta, kauluai, mimica, and soonae, based on a variety of morphological characters, most specifically the chaetotaxy of the labellae and the forelegs of males. A key to all taxa in the mimica subgroup is provided. The ecological associations of this species subgroup are also reviewed. We report host use from 13 of the 20 mimica subgroup species.